李明星 （LI, Mingxing）

博士，副研究员，硕士研究生导师。

邮箱：star.lee@hotmail.com

办公室地址：泸州市龙马潭区商贸城17区B座3层5街川南医学转化研究院

主要研究方向：(1)肿瘤微环境中的细胞crosstalk在消化道肿瘤进展中的作用及机制研究；(2)维生素D靶向CAFs改善胃癌微环境的机制研究；(3)新型抗胃癌药物的开发与应用。关于维生素D在消化道治疗中的应用与机理研究，取得了丰硕的成果，为临床应用与维生素D治疗消化道疾病提供了有力的理论基础和依据。截止目前，已发表SCI论文20余篇，包括Pharmacological Research，Nutritions，Autophagy，International Journal of Biological Sciences, Acta Pharmaceutica Sinica B，ACS Materials & Interfaces等生物学医学权威杂志，并参与编写1本领域专著。主持1项国家自然科学基金，1项四川省科技厅项目，1项泸州市人民政府-天天棋牌联合项目，参与多项国家自然科学基金面上项目与省部级课题。入选2021-2023期天天棋牌青年科技人才特别培育计划。

教育背景：

Ph.D. 香港中文大学，生物医学学院，生物医学

M.Sc. 四川大学，生物治疗国家重点实验室，细胞生物学

B.Sc. 山东师范大学，生命科学学院，生物技术

代表性论文：

1. Li, Qianxiu; Li, Yifan; Jiang, Houxiang; Xiao, Zhangang; Wu, Xu; Zhang, Hanyu; Zhao, Yueshui; Du, Fukuan; Chen, Yu; Wu, Zhigui; Li, Jing; Hu, Wei; Cho, Chi Hin; Shen, Jing*; Li, Mingxing*. Vitamin D suppressed gastric cancer cell growth through downregulating CD44 expression in vitro and in vivo. Nutrition. 2021 Nov-Dec;91-92:111413.

2. Li, Yifan; Lu, Lan; Wu, Xu; Li, Qianxiu; Zhao, Yueshui; Du, Fukuan; Chen, Yu; Shen, Jing; Xiao, Zhangang; Wu, Zhigui; Hu, Wei; Cho, Chi Hin; Li, Mingxing*. The Multifaceted Role of Long Non-Coding RNA in Gastric Cancer: Current Status and Future Perspectives. International Journal of Biological Sciences. 2021 Jun 26;17(11):2737-2755. (JCR Q2, 2021IF: 10.750)

3. Zhang, Hanyu#; Yang, Min#; Wu, Xu; Li, Qianxiu; Li, Xin; Zhao, Yueshui; Du, Fukuan; Chen, Yu; Wu, Zhigui; Xiao, Zhangang; Shen, Jing; Wen, Qinglian; Hu, Wei; Cho, Chi Hin; Chen, Meijuan*; Zhou, Yejiang*; Li, Mingxing*. The distinct roles of exosomes in tumor-stroma crosstalk within gastric tumor microenvironment. Pharmacological Research. 2021 Sep;171:105785. (JCR Q2, 2021IF: 10.334)

4. Yin J, Zhang H, Wu X, Zhang Y, Li J, Shen J, Zhao Y, Xiao Z, Lu L, Huang C, Zhang Z, Du F, Wu Y, Parham Jabbarzadeh Kaboli, Cho CH, Yuan D*, Li M*. CD44 inhibition attenuates EGFR signaling and enhances cisplatin sensitivity in human EGFR wild-type non-small-cell lung cancer cells. International Journal of Molecular Medicine. 2020(45):1783-1792.

5. Xu Wu, Jing Shen, Zhangang Xiao, Jing Li, Yueshui Zhao, Qijie Zhao, Chi Hin Cho*, Mingxing Li*. An overview of the multifaceted roles of miRNAs in gastric cancer: Spotlight on novel biomarkers and therapeutic targets. Biochemical Pharmacology, 2019(163):425-439.

6. Wu X, Hu W, Lu L, Zhao Y, Zhou Y, Li X, Li W, Zhang H, Xiao Z, Zhang L, Cho CH, Shen J*, Li MX*. Repurposing Vitamin D for Treatment of Human Malignancies via Targeting Tumor Microenvironment, Acta Pharmaceutica Sinica B. 2019;9(2):203–219.

7. Hu W^#, Zhang L^#, Li MX^#, Shen J^#, Liu XD, Xiao ZG, Wu DL, Ho IHT, Wu JCY, Cheung CKY, Zhang YC, Lau AHY, Ashktorab H, Smoot DT, Fang EF, Chan MTV, Gin T*, Gong W*, Wu WKK*, Cho CH*. Vitamin D3 activates the autolysosomal degradation function against Helicobacter pylori through PDIA3 receptor in gastric epithelial cells. Autophagy 2019:1-19.
   

8. Li MX, Li LF, Zhang L, Hu W, Shen J, Xiao Z, Wu X, Chan FL, Cho CH. 1,25-Dihydroxyvitamin D3 suppresses gastric cancer cell growth through VDR- and mutant p53-mediated induction of p21. Life sciences. 2017; 179:88-97.

9. Li MX, Li LF, Zhang L, Xiao Z, Shen J, Hu W, Zeng Q, Cho CH. Vitamin D and Cancer Stem Cells in the Gastrointestinal Tract. Current Medicinal Chemistry. 2017;24(9):918-927. 

10. Li MX, Liu P, Gao G, Deng J, Pan Z, Wu X, Xie G, Yue C, Cho CH, Ma Y and Cai L*. Smac therapeutic Peptide nanoparticles inducing apoptosis of cancer cells for combination chemotherapy with Doxorubicin. ACS Applied Materials & Interfaces. 2015; 7(15):8005-8012.