陈禹 (CHEN, Yu)

博士，四川省海外高层次留学人才。

E-mail: chenyu2021@swmu.edu.cn

办公地址：四川省泸州市龙马潭区商贸城17区B座3层5街川南医学转化研究院112室

个人简介：

陈禹，男，中共党员，博士。1991年4月出生于四川省宜宾市。2013年于中国海洋大学获医学学士学位，2016年于山东大学获药学硕士学位，2020年于香港中文大学合成化学国家重点实验室获哲学博士学位。2020年9月至今为天天棋牌药学院和川南医学转化研究院专任教师，研究兴趣：发展过渡金属催化C–H键活化、脱氢偶联反应、类药小分子合成及抗肿瘤药物化学。迄今在ACS Catalysis, Science China Chemistry, Chemical Communications, Organic Letters, Molecular Therapy-Oncolytics 等期刊发表SCI论文40余篇，其中通讯和一作10余篇。获得国家奖学金，山东大学药学院优秀学生，香港中文大学优秀教学助理，泸州市药学会优秀论文，四川省海外高层次留学人才等荣誉。指导硕士研究生、本科生毕业设计和大创项目，已毕业硕士生、本科生各2名，毕业生去往美国塔夫茨大学、山东理工大学等高校继续深造，或进入强生等知名药企。作为项目负责人目前主持科研项目3项，包括 (1)川大-泸州科技创新平台建设项目2022CDLZ-20，50万元；(2)天天棋牌校级项目2021ZKQN106，2万元；(3)天天棋牌科研启动经费0500040174，19万元。

代表性研究论文：(?Co-first)

1. Liyao Tang,^? Yan Zhang,^? Jinrun Xu,^? Qingfan Yang, Fukuan Du, Xu Wu, Mingxing Li, Jing Shen, Shuai Deng, Yueshui Zhao,* Zhangang Xiao,* and Yu Chen.* Synthesis of Oleanolic Acid-Dithiocarbamate Conjugates and Evaluation of Their Broad-Spectrum Antitumor Activities. Molecules, 2023, 28, 1414.

2. Mengyue Wang^?, Yu Chen^?, Cen Tang*, Recent Advances in Ligand Engineering for Gold Nanocluster Catalysis: Ligand Library, Ligand Effects and Strategies, Chem. Asian J., 2023, e202300463.

3. Yu Chen, Hairong Lyu, Yangjian Quan, Zuowei Xie.* Fe-Catalyzed Intramolecular B–H/C–H Dehydrogenative Coupling: Synthesis of Carborane-Fused Nitrogen Heterocycles. Org. Lett., 2021, 23, 4163–4167.

4. Peng Zhou, Yu Chen, Zuowei Xie.* Iron-Catalyzed Selective B–H Activation for 4/5-fold Methylation and Arylation of Carboranes. ACS Catal. 2022, 12, 8761–8767.

5. Yu Chen,^? Yik Ki Au,^? Yangjian Quan,* Zuowei Xie.* Copper Catalyzed/Mediated Direct B-H Alkenylation/Alkynylation in Carboranes. Sci. China Chem., 2019, 62, 74–79. 封面论文

6. Yu Chen, Yangjian Quan,* Zuowei Xie.* Ir-catalyzed Selective Dehydrogenative Crosscoupling of Aryls with o-carboranes via a Mixed Directing-Group Strategy. Chem. Commun., 2020, 56, 7001–7004.

7. Yu Chen, Yangjian Quan,* Zuowei Xie.* 8-Aminoquinoline as a bidentate traceless directing group for Cu-catalyzed selective B(4,5)-H disulfenylation of o-carboranes. Chem. Commun., 2020, 56, 12997–13000.

8. Yu Chen,^? Fukuan Du,^? Liyao Tang,^? Jinrun Xu, Yueshui Zhao, Xu Wu, Mingxing Li, Jing Shen, Qinglian Wen, Chi Hin Cho, Zhangang Xiao.* Carboranes as unique pharmacophores in antitumor medicinal chemistry. Mol. Ther. - Oncolytics, 2022, 24, 400–416.

9. Yu Chen,^? Qingfan Yang,^? Jinrun Xu,^? Liyao Tang, Yan Zhang, Fukuan Du, Yueshui Zhao, Xu Wu, Mingxing Li, Jing Shen, Ruiling Ding, Hongying Cao, Yu Du,* Qinglian Wen,* Zhangang Xiao.* PROTACs in Gastrointestinal Cancers, Mol. Ther. - Oncolytics, 2022,  27, 204-223.

10. Biao Cheng,^? Yu Chen,^? Peng Zhou, Zuowei Xie.* Rhodium-catalyzed sequential B(3)-, B(4)-, and B(5)-trifunctionalization of o-carboranes with three different substituents. Chem. Commun., 2022, 58, 629–632. 封面论文

11. Biao Cheng,^? Yu Chen,^? Zuowei Xie.* Iridium-Catalyzed Annulation of o?Carboranyl Carboxylic Acids with Alkynes: Synthesis of Carborano-Isocoumarins. J. Org. Chem. 2021, 86, 12412–12418.

12. Yao Zhang,^? Yu Chen,^? Yue Wan,^? Yueshui Zhao, Qinglian Wen, Xiaolong Tang, Jing Shen, Xu Wu, Mingxing Li, Xiang Li, Jing Li, Wanping Li,* Zhangang Xiao,* Fukuan Du.* Circular RNAs in the Regulation of Oxidative Stress. Front. Pharmacol., 2021, 12, 697903.

13. Qingfan Yang,^? Yu Chen,^? Rui Guo, Yalan Dai, Liyao Tang, Yueshui Zhao, Xu Wu, Mingxing Li, Fukuan Du, Jing Shen, Tao Yi*, Zhangang Xiao*, Qinglian Wen*. Interaction of ncRNA and epigenetic modifications in gastric cancer：Focus on histone modification. Front. Oncol., 2022, 11, 822745.

14. Yu Chen,^? Li Su,^? Xinying Yang, Wenyan Pan, Hao Fang.* Enantioselective Synthesis of 3,5-disubstituted Thiohydantoins and Hydantoins. Tetrahedron, 2015, 71, 9234–9239.